The best way to save the most money is by using coupons, but even they have to be organized too! I have mine in order by category, and then by expiration date, with the most recent expiring ones in the front.
I got this lovely coupon holder from ebay and I just can't live without it.
Sharing coupons is also a great way to help someone else out. So, if you have a coupon that you know you wont use before its expiration, give it to a friend or while in the store, leave it near the product the coupon is for. Someone did this at Walmart on my last visit and I was most appreciative.